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INTRODUCTION ADDPERAM 2 TABLET contains Perampanel which belongs to the group of medicines called Anticonvulsants. It is used in association with other antiepileptic drugs to treat seizures such as partial seizures (fits that affect one part of the brain) with or without secondary generalisati...
ADDPERAM 2 TABLET contains Perampanel which belongs to the group of medicines called Anticonvulsants. It is used in association with other antiepileptic drugs to treat seizures such as partial seizures (fits that affect one part of the brain) with or without secondary generalisation (fits affecting all the brain) in adults, adolescents (12 years and above) and children (4 to 11 years of age).
It is also used to treat generalized seizures (fits that affect all the brain and cause convulsions or starting spells) in adults, adolescents (12 years and above) and children (7 to 11 years of age).
Seizure is a disorder in which nerve cell activity in the brain is disturbed and during seizures person may experience abnormal behaviour, symptoms and sensations including loss of consciousness.
Perampanel blocks certain chemicals that regulate a broad spectrum of processes in the brain, spinal cord, retina, and nerves. These chemicals are excessively produced during the sudden disruption of the brain’s normal electrical activity that results in epileptic fits. This inhibitory action enables sufficient control over seizures without substantial impairment of brain function.
ADDPERAM 2 TABLET is not recommended for use in patients with serious liver problems, moderate or serious kidney problems or patients allergic to perampanel or if you have ever developed a severe skin rash or skin peeling, blistering or mouth sores after taking perampanel. It should be used with caution in patients having a history of substance abuse.
ADDPERAM 2 TABLET is not recommended for use in pregnant women or women planning for pregnancy and in breastfeeding women. ADDPERAM 2 TABLET is not recommended for use in children below 4 years of age (for partial seizures) and children below 7 years of age (for generalized seizures). The most common side effects of ADDPERAM 2 TABLET are dizziness, drowsiness, weight gain, irritable, anxious, or confusion. Talk to your doctor if any of the symptoms get worsen.
It is used in combination with other antiepileptics to treat certain types of epilepsy:
ADDPERAM 2 TABLET blocks certain chemicals that regulate a broad spectrum of processes in the brain, spinal cord, retina, and nerves. These chemicals are excessively produced during the sudden disruption of the brain’s normal electrical activity that results in epileptic fits. This inhibitory action enables sufficient control over seizures without substantial impairment of brain function.
Take ADDPERAM 2 TABLET as advised by your physician. Swallow the medicine whole with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
Stop taking ADDPERAM 2 TABLET and contact your doctor immediately if you experience any of the following side effects:
Sit down or lie down slowly when you are feeling dizziness. Take rest for some time and drink plenty of water. Avoid coffee and other carbonated drinks. If the symptom does not improve, contact your doctor.
Try to relax and rest yourself. Apply pain balm to the head to ease off the pain. Sip on some hot water or ginger tea. If the symptom does not improve, contact your doctor.
Take this medicine along with, or just after meals. Stick to simple meals and avoid eating oil rich or spicy foods. If the symptom does not improve, contact your doctor.
Drink plenty of fluid and eat balanced diet and frequent meals. Do regular minimal exercise and follow regular sleep schedule. If the symptom does not improve, contact your doctor.
ADDPERAM 2 TABLET is not recommended for use in pregnant women. Women of child-bearing potential should use reliable method of contraception to avoid becoming pregnant while taking ADDPERAM 2 TABLET, also continue this for one month after stopping the treatment. Consult your doctor before taking ADDPERAM 2 TABLET.
ADDPERAM 2 TABLET is generally not recommended for use in breastfeeding women unless considered clearly necessary. Consult your doctor before taking ADDPERAM 2 TABLET.
Do not drive or operate any machines if you feel dizzy or sleepy after taking ADDPERAM 2 TABLET. Consult your doctor before taking ADDPERAM 2 TABLET.
Avoid consumption of alcohol while taking ADDPERAM 2 TABLET because it might make you dizzier and can also worsen the feelings of anger, confusion, or sadness. Consult your doctor before taking ADDPERAM 2 TABLET.
ADDPERAM 2 TABLET is not recommended for use in patients with moderate or serious kidney problems. Consult with your doctor before taking ADDPERAM 2 TABLET.
ADDPERAM 2 TABLET is not recommended for use in patients with serious liver problems and it should be used with caution in patients with liver problems. Consult with your doctor before taking ADDPERAM 2 TABLET.
Do not take ADDPERAM 2 TABLET if you are allergic to Perampanel.
ADDPERAM 2 TABLET is generally not recommended for use in children under 4 years of age for partial seizures and under 7 years of age for generalized seizures due to lack of safety and effectiveness. It should be used with caution in children (4 to 11 years of age) for partial seizures and (7 to 11 years of age) for generalized seizures. Your doctor will adjust the dose based on the body weight. Consult your doctor before taking this ADDPERAM 2 TABLET.
ADDPERAM 2 TABLET should be used with caution in elderly patients (aged 65 years and above). Consult your doctor before taking this ADDPERAM 2 TABLET.
Before taking ADDPERAM 2 TABLET, inform your doctor if you:
A. Drug-Drug interactions:
Before taking ADDPERAM 2 TABLET, inform your doctor if you are taking any of the following medicine:
Overdosage:
If you or anyone else accidentally take too much of ADDPERAM 2 TABLET, consult your doctor immediately or visit the nearby hospital. Symptoms of overdose are confusion, agitation, aggressive behaviour, and depressed level of consciousness.
| Drug | : | Perampanel |
| Pharmacological Category | : | Anticonvulsants |
| Therapeutic Indication | : | Partial and generalized seizures |
| Dosage Forms | : | Tablet |
Q: What is ADDPERAM 2 TABLET used for?
A: ADDPERAM 2 TABLET is used in association with other anti-epileptic drugs to treat partial seizures (fits that affect one part of the brain), with or without secondary generalization in patients who are 4 years of age and older, also used to treat generalized seizures (fits that affect the entire brain) in patients who are 12 years of age and older.
Q: What should I avoid while taking ADDPERAM 2 TABLET?
A: Avoid consuming alcohol while taking ADDPERAM 2 TABLET because it might make you sleepier and dizzier. You should also avoid driving and using heavy machinery after taking ADDPERAM 2 TABLET and consult your concern with your doctor before starting to take this medicine.
Q: What will happen if I suddenly stop taking ADDPERAM 2 TABLET?
A: You should not suddenly stop taking ADDPERAM 2 TABLET. Take as long as your doctor recommends. ADDPERAM 2 TABLET can cause physical dependence, which means that abruptly discontinuing can result in symptoms such as anxiety, nervousness, irritability, fatigue, weakness, lethargy, mood swings, and sleeplessness.
Q: What are the health tips to be followed while taking ADDPERAM 2 TABLET to prevent seizures?
A: Take a healthy diet along with regular exercise, practice yoga every day, get enough sleep, limit the use of screen time such as mobile or laptop and remember to take ADDPERAM 2 TABLET on time. Follow these health tips after consulting your doctor.
Q: Does taking ADDPERAM 2 TABLET affect my mental health?
A: Yes, while taking ADDPERAM 2 TABLET you might experience extreme mood changes, increased aggressive behaviour and suicidal thoughts also might crop up in your mind. If any you experience any of these symptoms, please consult your doctor immediately.
1. KD. Tripathi. Antiepileptic Drugs. Essentials of medical pharmacology. Eighth edition. 2019. Page – 449.
2. Hansen, Cerine C., Hanna Ljung, Eylert Brodtkorb, and Arne Reimers. "Mechanisms underlying aggressive behaviour induced by antiepileptic drugs: focus on topiramate, levetiracetam, and perampanel." Behavioural neurology. [Revised in November 2018] [Accessed on 21st May 2022] https://doi.org/10.1155/2018/2064027
3. Trinka, Eugen, Simona Lattanzi, Kate Carpenter, Tommaso Corradetti, Bruna Nucera, Fabrizio Rinaldi, Rohit Shankar, and Francesco Brigo. "Exploring the evidence for broad-spectrum effectiveness of perampanel: a systematic review of clinical data in generalised seizures." CNS drugs. [Revised in July 2021] [Accessed on 21st May 2022] https://link.springer.com/article/10.1007/s40263-021-00831-y
4. Eisai Inc. U.S. Food & Drug Administration. [Revised in December 2021] [Accessed on 21st May 2022] https://www.fycompa.com/-/media/Files/Fycompa/Fycompa_Prescribing_Information.pdf
5. Eisai Manufacturing Limited. Electronic Medicines Compendium (EMC). [Revised in July 2021] [Accessed on 21st May 2022] https://www.medicines.org.uk/emc/files/pil.4276.pdf
Written By Dr. R. Dinesh John Rajkumar, Pharm.D
Last updated on 28 Feb 2023 | 10:06 AM(IST)